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Mining Plasmodium

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Compositions and methods for blocking transmission

According to the statistics of the World Health Organization, about 3.2 billion people are likely to be infected by Plasmodium and lead to malaria.

Plasmodium falciparum

Plasmodium falciparum is a protozoan parasite that causes an infectious disease called malaria. Plasmodium falciparum is the most serious form of malaria and is associated with almost all malaria deaths. The other three species causing malaria include Plasmodium vivax, Plasmodium ovale and Plasmodium. Malaria. Humans are infected by female Anopheles and transmit parasites

Structure based docking and molecular dynamic

Malaria parasites have an unparalleled history, and almost all drugs targeted at them are resistant. Over time, these parasites acquire complex strategies...

Mining the repertoire of essential lipases in the

Agricultural workers around the world are at greater risk of malaria because of outdoor work in mosquito rich environments. Malaria is a major public health burden in many tropical regions of the world, causing 500000 deaths and 200 million clinical outbreaks each year. To understand the basic biochemical process of parasite development in human host erythrocytes...

A fresh look at the origin of plasmodium falciparum,

4. The diversity of Plasmodium in great apes is higher than previously thought. Within a year, the diversity of known Plasmodium species that infect apes and belong to the Plasmodium falciparum lineage erupted. Until May 2009, only one species, P. reichenowi, was a sister lineage of Plasmodium falciparum

Investigating a plasmodium falciparum erythrocyte

Plasmodium falciparum malaria remains a major global public health challenge...

Blast biopython tutorial

Seven cases of Plasmodium falciparum were studied. We have a hypothesis that Plasmodium falciparum has adapted to the human body in its long history as a parasite. Specifically, we want to see if the protein of Plasmodium is closer to human protein than expected. If this is true, we can explain that more similar proteins help the parasite escape human immunity

Gold mining areas in suriname reservoirs of malaria ...

Molecular investigation of Plasmodium falciparum isolates from residents of gold mining areas was carried out to evaluate the extent and effect of the mining area as an antimalarial reservoir...

A plasmodiumlike virulence effector of the soybean

Inhibition of plant innate immunity by virulent effectors of soybean cyst nematode like Plasmodium... Dmitry korkin, Melissa g. Mitchum, mining new global effectors from transcriptome of early life stage of soybean cyst nematode, scientific report, 10.1038s41598-018-20536-51, August 1, 2018. Cross reference.

Applied genomics data mining reveals species

Accurate and rapid diagnosis of malaria infection is essential for the implementation of appropriate species therapy and life-saving. Molecular diagnostic tools are the most accurate and sensitive methods to detect Plasmodium, distinguish Plasmodium species and detect subclinical infection. Despite the genome-wide sequence data of Plasmodium falciparum and Plasmodium vivax, however...

Data mining of the transcriptome of plasmodium

Data mining of antioxidant defense transcriptome of Plasmodium falciparum. The early phagocytosis of G6PD deficient red blood cells of Plasmodium falciparum in 1998 may explain the protective effect of G6PD deficiency on malaria.

Novel rna viruses associated with plasmodium vivax

Although parasites are the main cause of human diseases, they themselves can also be infected by viruses. We asked if the three major Plasmodium species of Plasmodium vivax, Plasmodium falciparum and Plasmodium knowlesi were also infected with the virus. To this end, we performed a total RNA sequencing meta-analysis of human blood samples infected with these parasites...

Modeling cytoadhesion of plasmodium

In both cases of Plasmodium falciparum infected red blood cells adhering to microvascular endothelial lining cells and leukocytes, there are adherents on the cell surface. Another similarity is the enhancement of adhesion under the action of physical forces.

Schneider, gisbert

Ebiomedicine 5, 386395. Schneider, G. and Schneider, p.2015 inferred the association between macromolecular drug targets by self-organizing pharmacophore fingerprints. Cicsj bulletin 33, 25. Rodrigues, T. and Schneider, g., 2015 e-show hit

Genome miningbased identification of identical ...

Here, we use a new genome mining method to identify a pair of identical multiple repeat sequences (imrss) that make up 170 and 123 copies of Plasmodium falciparum genome, and explore their potential as PCR primers.

Welcome to the cui lab

In addition, through data mining and analysis, we found some interesting patterns and rules of these gender biased mRNAs and miRNAs. In addition, we propose a calculation method and develop a Java based computer program sexbiasedrug, which can be used to predict gender biased reactive drugs in specific organs and tissues (such as heart) on a large scale...

Data mining of the transcriptome of plasmodium

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Imaging of plasmodium liver stages to drive next ...

Malaria remains a major health challenge in many of the world's poorest countries, with 225 million cases in 2009 leading to an estimated 781000 deaths. In humans, malaria is caused by Plasmodium falciparum, Plasmodium malaria, Plasmodium ovale, Plasmodium vivax and Plasmodium simian. Malaria is transmitted naturally by the bite of an infected female Anopheles.

Malaria database interactions for plasmodium

Interaction of malaria database using text mining technology to extract Plasmodium falciparum protein

Antimalarial activity of artefenomel against asexual ...

Malaria is the leading cause of disease and death worldwide, with an estimated 405000 deaths in 2018. Although Plasmodium falciparum is the cause of most deaths, Plasmodium vivax is the major human Plasmodium species outside Africa and has been recognized as an important cause of severe morbidity and plays an important role in mortality 2 and 3.

Pdf mining regulatory elements in the plasmodium ...

Mining regulatory factors in Plasmodium falciparum genome using gene expression data

Genome wide in silico analysis of plasmodium

A total of 67 candidate phosphatases were found in Plasmodium falciparum by searching Plasmodium 9.2, Pfam and CDD. Although this amount is far less than that of phosphatase in Homo sapiens, it is almost the same as other Plasmodium species.

Out of africa origins and evolution of the human

Plasmodium falciparum and Plasmodium vivax account for more than 95% of human malaria infections and pose a serious challenge to public health. In order to control and potentially eliminate these pathogens, it is important to understand their origin and evolutionary history. Until recently, it was wi

Refining the transcriptome of the human malaria

During its complex life cycle, Plasmodium has undergone several major developmental changes, which are achieved through precise and orderly gene expression programs. Transcripts of the 48 hour blood phase of the major human Plasmodium falciparum have been described using cDNA microarrays and RNA sequences, but these analyses do not always perform well without coding

Prevalence of malaria parasites in people working in ...

Prevalence of malaria parasites among illegal gold mining workers in French Guiana. The safety and scientific validity of this study are the responsibility of the study's sponsors and researchers.

The plasmodium circumsporozoite protein is

Cyclosporidin protein CSP is the main surface protein of Plasmodium sporozoites, which is the infection stage of malaria. Although CSP has been widely studied as a candidate vaccine for malaria vaccine, little is known about its structure.

Data mining of the transcriptome of plasmodium

The general paradigm from the analysis of Plasmodium falciparum transcriptome is that the gene expression clusters encoding the same cellular functions are coordinated. Here, the consistency of this view is tested by analyzing specific metabolic pathways. The pentose phosphate pathway (PPP) is a new PPP method...

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